Association of Helicobacter Pylori With Development of Peptic Ulcer Disease Among Cirrhotic Patients: An Evidence From Population-Based Study

被引:1
|
作者
Yang, Tsu Jung [1 ]
Dhanasekar, Krithika [2 ]
Bhandari, Renu [3 ]
Muraleedharan, Divya [4 ]
Chirindoth, Swathy S. [5 ]
Kaur, Harpreet [6 ]
Goswami, Ruchir [7 ]
Maiyani, Prakash [8 ]
Desai, Maheshkumar [9 ]
Moradiya, Dharmeshkumar, V [10 ]
Devani, Hiteshkumar [11 ]
Patel, Achint A. [12 ]
机构
[1] MultiCare Good Samaritan Hosp, Hosp Med, Puyallup, WA 98372 USA
[2] Sterling Med Ctr, Internal Med, Sterling Hts, MI USA
[3] Manipal Coll Med Sci, Med, Kaski, Nepal
[4] Larkin Community Hosp, Internal Med, South Miami, FL USA
[5] Kannur Med Coll, Internal Med, Kannur, India
[6] Bronx Care, Internal Med, Bronx, NY USA
[7] Icahn Sch Med Mt Sinai, Epidemiol & Publ Hlth, New York, NY 10029 USA
[8] Gold Coast Univ Hosp, Internal Med, Southport, Qld, Australia
[9] Augusta Univ, Med Coll Georgia, Hamilton Med Ctr, Internal Med, Augusta, GA USA
[10] St John God Murdoch Hosp, Internal Med, Murdoch, WA, Australia
[11] Univ Pittsburgh, Sch Dent Med, Dent Med, Pittsburgh, PA USA
[12] Oak Hill Hosp, Internal Med, Brooksville, FL USA
关键词
prevalence study; population based study; live cirrhosis; peptic ulcer disease; helicobacter pylori; GASTRIC-ACID-SECRETION; ALCOHOL-CONSUMPTION; LIVER-CIRRHOSIS; ERADICATION THERAPY; INFECTION; RISK; EPIDEMIOLOGY; PREVALENCE; SMOKING;
D O I
10.7759/cureus.19315
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Helicobacter pylori (H. pylori) plays an important role in causing peptic ulcer disease (PUD) in the general population. However, the role of H. pylori in cirrhotic patients for causing PUD is obscure. There are various studies evaluating H. pylori association with PUD in cirrhotic patients, but the results have been controversial. We sought to analyze the association of H. pylori with the development of PUD in cirrhotic patients from the largest United States population-based database. Methods: We analyzed Nationwide Inpatient Sample (NIS) and Healthcare Cost and Utilization Project (HCUP) data from 2017. Adult hospitalizations due to cirrhosis were identified by previously validated ICD-10-CM codes. PUD and H. pylori were identified with the presence of ICD-10-CM codes in primary and secondary diagnosis fields, respectively. We performed weighted analyses using Chi-Square and paired Student's t-test to compare the groups. Multivariable survey logistic regression was performed to find an association of H. pylori with PUD in cirrhotic patients. Results: Our study showed that the prevalence of H. pylori infection was 2.2% in cirrhotic patients with PUD. In regression analysis, H. pylori was found to be associated with PUD in cirrhotic patients (OR 15.1; 95% CI: 13.9-16.4; p <0.001) and non-cirrhotic patients (OR 48.8; 95% CI: 47.5-50.1; p <0.001). In the studied population, H. pylori was more commonly seen in the age between 50 and 64 years (49.4% vs 44.1%; p <0.0001), male (63.4% vs 59.9%; p <0.0413), African American (16.3% vs 10.6%; p <0.0001), and Hispanic (26.2% vs 14.9%; p <0.0001). H. pylori is more likely to be associated with complicated PUD hospitalizations (51.2% vs 44.2%; p <0.0067). Alcoholism and smoking were more common in H. pylori group compared to those without (43.6% vs 35.8%; p <0.0001 and 33.7% vs 24.8% p <0.0001, respectively). Factors associated with increased odds of H. pylori infection include African American (OR 2.3, 95% CI: 1.5-3.6), Hispanic (OR 2.6, 95% CI: 1.7-4.0), and smoking (OR 1.5, 95% CI: 1.1-2.2). Conclusion: H. pylori are associated with PUD and concurrent cirrhosis, although it is less prevalent than general population. African American, Hispanic, and smoking were independently associated with increased odds of H. pylori infection. Further studies are required to better understand the epidemiology and confirm our findings.
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页数:9
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