Visible-Light-Mediated Synthesis of α-Halomethyl Ketones from Terminal Alkynes

被引：2

作者：

Shah, Iftkhar Hussain ^{[1
,3
]}

Kumar, Sourav ^{[1
,3
]}

Kumar, Jaswant ^{[1
,3
]}

Raheem, Shabnam ^{[2
]}

Rizvi, Masood Ahmad ^{[2
]}

Shah, Bhahwal Ali ^{[1
,3
]}

机构：

[1] Acad Sci & Ind Res AcSIR, Ghaziabad 201002, India

[2] Univ Kashmir, Srinagar 190006, India

[3] CSIR Indian Inst Integrat Med, Nat Prod & Med Chem, Canal Rd, Jammu 180001, India

来源：

CHEMPHOTOCHEM | 2022年 / 6卷 / 03期

关键词：

alpha-halomethyl ketones; alkynes; N-halosuccinimide; radicals; trifluoroacetic acid; CATALYZED HYDRATION; N-HALOSUCCINIMIDES; CASCADE REACTION; MILD; HALOGENATION; FUNCTIONALIZATION; HALOKETONES; DERIVATIVES; HALOALKYNES; CONVENIENT;

D O I：

10.1002/cptc.202100231

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A visible-light-assisted approach for the synthesis of alpha-halomethyl ketones from terminal alkynes has been developed. The reaction introduces halogen at the alpha-position of terminal alkynes using N-halosuccinimides as the halogen source. It relies on the photodegradation of N-halosuccinimides obviating the requirement for a photocatalyst. The procedure enables the synthesis of a diverse range of alpha-haloketones from different aromatic bromo- and iodoalkynes.

引用

页数：5

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