A Genomic Signature [JAK2, JAK3, PIAS4, PTPN2, STAT3, IFNAR2] Predicts Baseline Resistance to Nivolumab in Advanced NSCLC.

被引：0
|
作者：
Pilotto, S. [1 ]
Grizzi, G. [1 ]
Sperduti, I. [2 ]
Simbolo, M. [3 ]
Vicentini, C. [3 ]
Calio, A. [3 ]
Caccese, M. [1 ]
Mafficini, A. [3 ]
Carbognin, L. [1 ]
Corbo, V. [3 ]
Gkountakos, A. [3 ]
Santo, A. [1 ]
Infante, M. [4 ]
Brunelli, M. [3 ]
Scarpa, A. [3 ]
Tortora, G. [1 ]
Bria, E. [5 ]
机构：
[1] Univ Verona, Aoui, Med Oncol, Verona, Italy
[2] Regina Elena Inst Canc Res, Rome, Italy
[3] Univ & Hosp Trust Verona, Sect Anat Pathol, Dept Diagnost & Publ Hlth, Verona, Italy
[4] Osped Borgo Trento, Univ & Hosp Trust, Verona, Italy
[5] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, Div Med Oncol, Rome, Italy
来源：
JOURNAL OF THORACIC ONCOLOGY | 2018年 / 13卷 / 10期
关键词：
Genomic signature; advanced NSCLC; Immunotherapy resistance;
D O I：
10.1016/j.jtho.2018.08.1236
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
P2.04-12
引用
收藏
页码：S734 / S735
页数：2
相关论文
共 50 条
  • [31] FANCD2 inhibits ferroptosis by regulating the JAK2/STAT3 pathway in osteosarcoma
    Xujun Li
    Jiangyi Liu
    BMC Cancer, 23
  • [32] Complete genomic organization and promoter analysis of the round-spotted pufferfish JAK1, JAK2, JAK3, and TYK2 genes
    Leu, JH
    Yan, SJ
    Lee, TF
    Chou, CM
    Chen, ST
    Hwang, PP
    Chou, CK
    Huang, CJ
    DNA AND CELL BIOLOGY, 2000, 19 (07) : 431 - 446
  • [33] JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma
    Zheng, Qifan
    Han, Lei
    Dong, Yucui
    Tian, Jing
    Huang, Wei
    Liu, Zhaoyu
    Jia, Xiuzhi
    Jiang, Tao
    Zhang, Jianning
    Li, Xia
    Kang, Chunsheng
    Ren, Huan
    NEURO-ONCOLOGY, 2014, 16 (09) : 1229 - 1243
  • [34] Cyclanoline Reverses Cisplatin Resistance in Bladder Cancer Cells by Inhibiting the JAK2/STAT3 Pathway
    Li, Linjin
    Li, Chengpeng
    Miao, Feilong
    Chen, Wu
    Kong, Xianghui
    Ye, Ruxian
    Wang, Feng
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2024, 24 (18) : 1360 - 1370
  • [35] Inhibition of JAK2/STAT3/SOCS3 signaling attenuates atherosclerosis in rabbit
    Yang, Xilan
    Jia, Jian
    Yu, Zhen
    Duanmu, Zheng
    He, Huiwei
    Chen, Sen
    Qu, Chen
    BMC CARDIOVASCULAR DISORDERS, 2020, 20 (01)
  • [36] Inhibition of JAK2/STAT3/SOCS3 signaling attenuates atherosclerosis in rabbit
    Xilan Yang
    Jian Jia
    Zhen Yu
    Zheng Duanmu
    Huiwei He
    Sen Chen
    Chen Qu
    BMC Cardiovascular Disorders, 20
  • [37] JAK2/STAT3/SOCS3信号通路与肿瘤转移
    蒋树龙
    花宝金
    中国肿瘤生物治疗杂志, 2014, 21 (06) : 698 - 702
  • [38] Effects of JAK2/STAT3 Signaling Pathway Activation on Intracellular Survival of Brucella
    Yi, Jihai
    Wang, Yueli
    Zhang, Junbo
    Xu, Jinfeng
    Li, Tiansen
    Chen, Chuangfu
    PAKISTAN VETERINARY JOURNAL, 2018, 38 (02) : 153 - 158
  • [39] Aβ causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons
    Chiba, Tomohiro
    Yamada, Marina
    Terashita, Kenzo
    Aiso, Sadakazu
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 : 52P - 52P
  • [40] VSIG4 Silencing Inhibits Glioblastoma Growth by Regulating the JAK2/STAT3 Pathway
    Zheng, Congying
    Mao, Chengliang
    Tang, Kai
    Shu, Hang
    NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2023, 19 : 1397 - 1408
12345