A Weinreb Amide Based Building Block for Convenient Access to β,β-Diarylacroleins: Synthesis of 3-Arylindanones

被引：9
|
作者：
Tiwari, Praveen Kumar [1 ]
Aidhen, Indrapal Singh [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 15期
关键词：
Synthetic methods; C3 Building blocks; Amides; Grignard reaction; HECK REACTION; ASYMMETRIC-SYNTHESIS; CARBOXYLIC-ACIDS; (+)-INDATRALINE; HYDROGENATION; DERIVATIVES; ANTAGONISTS; ALDEHYDES; INDANONES; AGONISTS;
D O I：
10.1002/ejoc.201600193
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Towards the synthesis of symmetrical and unsymmetrical beta,beta-diarylacroleins for assembling diarylmethine fragments present in biologically important molecules, we have developed a new Weinreb amide (WA) based building block, derived from propiolic acid. The WA functionality present in this compound allowed the sequential addition of various arylmagnesium bromide reagents in a controlled manner. The developed methodology for the access to beta,beta-diarylacroleins has been utilised for the synthesis of biologically important 3-arylindanone molecules.
引用
收藏
页码：2637 / 2646
页数：10
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