Ir-catalyzed asymmetric hydrogenation of 3-arylindenones for the synthesis of chiral 3-arylindanones

被引：11

作者：

Yan, Jun ^{[1
]}

Nie, Yu ^{[1
]}

Gao, Feng ^{[1
]}

Yuan, Qianjia ^{[1
]}

Xie, Fang ^{[1
]}

Zhang, Wanbin ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

来源：

TETRAHEDRON | 2021年 / 84卷

基金：

中国国家自然科学基金;

关键词：

Iridium; Asymmetric hydrogenation; Chiral; 3-arylindanone; Axis-unfixed; Phosphine-oxazoline; ENANTIOSELECTIVE SYNTHESIS; (+)-INDATRALINE; HYDROACYLATION; 3-ARYL-1-INDANONES; INDATRALINE; INDUCTION; DESIGN;

D O I：

10.1016/j.tet.2021.132003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of chiral 3-arylindanones via iridium-catalyzed asymmetric hydrogenation of 3-arylindenones has been developed. The reaction showed good compatibility with various functional groups, delivering a variety of 3-arylindanones in excellent yields and with good enantioselectivities. The reaction was also carried out on a gram-scale, delivering the product in quantitative yield. In addition, the products can be easily derivatized and transformed into natural products and pharmaceutical agents. (c) 2021 Elsevier Ltd. All rights reserved.

引用

页数：8

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