Constituents of the stem barks of Ailanthus altissima and their potential to inhibit LPS-induced nitric oxide production

被引：38

作者：

Kim, Hye Mi ^{[1
]}

Kim, Su Jung ^{[1
]}

Kim, Ha-Yeong ^{[2
]}

Ryu, Byeol ^{[2
]}

Kwak, Hokwang ^{[2
]}

Hur, Jonghyun ^{[3
]}

Choi, Jung-Hye ^{[1
,2
]}

Jang, Dae Sik ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

[2] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea

[3] Whan In Pharm Co Ltd, Cent Res Inst, Suwon 443766, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Ailanthus altissima; Simaroubaceae; Canthinone type alkaloids; Nitric oxide; Inflammation; MILL; SWINGLE; LEAVES; SEEDS;

D O I：

10.1016/j.bmcl.2015.01.034

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new canthinone type alkaloids, canthin-6-one-1-O-beta-D-apiofuranosyl-(1 -> 2)-beta-D-glucopyranoside (1), canthin-6-one-1-O-[6-O-(3-hydroxy-3-methylglutaryl)]-beta-D-glucopyranoside (2) and canthin-6-one-1-O-[2-beta-D-apiofuranosyl-6-O-(3-hydroxy-3-methylglutaryl)]-beta-D-glucopyranoside (3) were isolated from the stem barks of Ailanthus altissima together with four quassinoids (4-7), seven phenylpropanoids (8-14) and a lignan of previously known structure (15). The inflammatory activities of the 15 isolates were screened on LPS-induced nitric oxide (NO), a proinflammatory mediator, in RAW 264.7 cells. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1017 / 1020

页数：4

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