Constituents of the stem barks of Ailanthus altissima and their potential to inhibit LPS-induced nitric oxide production

被引：38
|
作者：
Kim, Hye Mi [1 ]
Kim, Su Jung [1 ]
Kim, Ha-Yeong [2 ]
Ryu, Byeol [2 ]
Kwak, Hokwang [2 ]
Hur, Jonghyun [3 ]
Choi, Jung-Hye [1 ,2 ]
Jang, Dae Sik [1 ,2 ]
机构：
[1] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea
[2] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea
[3] Whan In Pharm Co Ltd, Cent Res Inst, Suwon 443766, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
Ailanthus altissima; Simaroubaceae; Canthinone type alkaloids; Nitric oxide; Inflammation; MILL; SWINGLE; LEAVES; SEEDS;
D O I：
10.1016/j.bmcl.2015.01.034
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new canthinone type alkaloids, canthin-6-one-1-O-beta-D-apiofuranosyl-(1 -> 2)-beta-D-glucopyranoside (1), canthin-6-one-1-O-[6-O-(3-hydroxy-3-methylglutaryl)]-beta-D-glucopyranoside (2) and canthin-6-one-1-O-[2-beta-D-apiofuranosyl-6-O-(3-hydroxy-3-methylglutaryl)]-beta-D-glucopyranoside (3) were isolated from the stem barks of Ailanthus altissima together with four quassinoids (4-7), seven phenylpropanoids (8-14) and a lignan of previously known structure (15). The inflammatory activities of the 15 isolates were screened on LPS-induced nitric oxide (NO), a proinflammatory mediator, in RAW 264.7 cells. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1017 / 1020
页数：4
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