Antidepressants in clinical practice: Limitations of assessment methods and drug response

被引:35
|
作者
Kennedy, SH [1 ]
Eisfeld, BS [1 ]
Meyer, JH [1 ]
Bagby, RM [1 ]
机构
[1] Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON M5T 1RB, Canada
关键词
antidepressants; efficacy; diagnostic heterogeneity functional brain imaging; Major Depressive Disorder;
D O I
10.1002/hup.189
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
There is a recognized gap between knowledge derived from 'efficacy' data - based on usually brief randomized controlled trials and findings in natural practice 'effectiveness' studies. In considering the limitations of current antidepressants in clinical practice, we have selected three clinically important issues to examine in a natural practice data base that has been in existence for several years. These relate to: (I) Diagnostic heterogeneity and potential advances using functional brain imaging; (2) Variability of outcome measures during treatment and (3) Time to response and prediction of outcome. Copyright (C) 2001 John Wiley & Sons, Ltd.
引用
收藏
页码:105 / 114
页数:10
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