The natural history of monoclonal villous lymphocytosis: A chronic lymphoproliferative disorder of CD11c+ B cells

被引：2
|
作者：
Bassan, R
Amaru, R
Rambaldi, A
Ruggeri, M
Borleri, GM
Barbui, T
机构：
[1] Hospital Papa Giovanni XXIII, La Paz
[2] Divisione di Ematologia, Ospedali Riuniti, 24100 Bergamo
来源：
LEUKEMIA & LYMPHOMA | 1996年 / 21卷 / 1-2期
关键词：
villous lymphocytosis; evolution; cytokines; CD11c+; lymphocytosis;
D O I：
10.3109/10428199609067598
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The long-term outcome of three asymptomatic subjects with isolated persistent lymphocytosis of monoclonal villous B-cells (MVL) is reviewed. After 7.5 years, evolution to a splenic lymphoma variant (SLVL) was documented in only one patient, accompanied by a loss of interleukin-1 beta autocrine production, confirming that MVL can be an early form of a malignant disorder. The clinical course was uneventful in the other two cases; a progressive lowering of lymphocyte count being noted in one. While the strict relationship of MVL to SLVL is confirmed, time to progression is unpredictable and the mechanisms by which it occurs still remain to be elucidated.
引用
收藏
页码：181 / 183
页数：3
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