Context-Dependent Pharmacological Effects of Metformin on the Immune System

被引：41
|
作者：
Marcucci, Fabrizio [1 ]
Romeo, Elisabetta [2 ]
Caserta, Carmelo A. [2 ]
Rumio, Cristiano [1 ]
Lefoulon, Francois [3 ]
机构：
[1] Univ Milan, Dept Pharmacol & Biomol Sci, Via Trentacoste 2, Milan, Italy
[2] Fdn Med Solidale, Via San Cosimo 8 Pellaro, Reggio Di Calabria, Italy
[3] Technol Servier, Dept Synth, Orleans, France
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2020年 / 41卷 / 03期
关键词：
REGULATORY T-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-GROWTH; MEDIATED INHIBITION; MAMMALIAN TARGET; HELPER; 17; CANCER; AMPK; SUPPRESSES; DRUG;
D O I：
10.1016/j.tips.2020.01.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Metformin is used for the treatment of type 2 diabetes mellitus and has shown therapeutic effects in preclinical models of other pathologies, such as cancer and autoimmune diseases. The antitumor activity of metformin is due, in part, to immunostimulatory effects. In the context of other pathologies, such as autoimmune or inflammatory diseases, metformin has immunosuppressive effects. There is evidence that the immunostimulatory effects of metformin are indirect. The immunosuppressive effects of metformin in other pathologies appear to be a direct consequence of its action on immune cells. Based on these observations we opine that the pharmacology of metformin is dependent on the pathological context which, to our knowledge, is a novel concept in pharmacology.
引用
收藏
页码：162 / 171
页数：10
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