Context-Dependent Pharmacological Effects of Metformin on the Immune System

被引：41

作者：

Marcucci, Fabrizio ^{[1
]}

Romeo, Elisabetta ^{[2
]}

Caserta, Carmelo A. ^{[2
]}

Rumio, Cristiano ^{[1
]}

Lefoulon, Francois ^{[3
]}

机构：

[1] Univ Milan, Dept Pharmacol & Biomol Sci, Via Trentacoste 2, Milan, Italy

[2] Fdn Med Solidale, Via San Cosimo 8 Pellaro, Reggio Di Calabria, Italy

[3] Technol Servier, Dept Synth, Orleans, France

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2020年 / 41卷 / 03期

关键词：

REGULATORY T-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-GROWTH; MEDIATED INHIBITION; MAMMALIAN TARGET; HELPER; 17; CANCER; AMPK; SUPPRESSES; DRUG;

D O I：

10.1016/j.tips.2020.01.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Metformin is used for the treatment of type 2 diabetes mellitus and has shown therapeutic effects in preclinical models of other pathologies, such as cancer and autoimmune diseases. The antitumor activity of metformin is due, in part, to immunostimulatory effects. In the context of other pathologies, such as autoimmune or inflammatory diseases, metformin has immunosuppressive effects. There is evidence that the immunostimulatory effects of metformin are indirect. The immunosuppressive effects of metformin in other pathologies appear to be a direct consequence of its action on immune cells. Based on these observations we opine that the pharmacology of metformin is dependent on the pathological context which, to our knowledge, is a novel concept in pharmacology.

引用

页码：162 / 171

页数：10

共 50 条

[1] System for context-dependent user modeling
Nurmi, Petteri
Salden, Alfons
Lau, Sian Lun
Suomela, Jukka
Sutterer, Michael
Millerat, Jean
Martin, Miquel
Lagerspetz, Eemil
Poortinga, Remco
[J]. ON THE MOVE TO MEANINGFUL INTERNET SYSTEMS 2006: OTM 2006 WORKSHOPS, PT 2, PROCEEDINGS, 2006, 4278 : 1894 - 1903
[2] Context-dependent genetic effects in hypertension
Kardia S.L.R.
[J]. Current Hypertension Reports, 2000, 2 (1) : 32 - 38
[3] CONTEXT-DEPENDENT EFFECTS ON ANALOGICAL TRANSFER
SPENCER, RM
WEISBERG, RW
[J]. MEMORY & COGNITION, 1986, 14 (05) : 442 - 449
[4] Context-Dependent Skeletal Effects of Erythropoietin
Hiram-Bab, Sahar
Neumann, Drorit
Gabet, Yankel
[J]. ERYTHROPOIETIN, 2017, 105 : 161 - 179
[5] Context-Dependent Effects of Goal Primes
Laran, Juliano
Janiszewski, Chris
Cunha, Marcus, Jr.
[J]. JOURNAL OF CONSUMER RESEARCH, 2008, 35 (04) : 653 - 667
[6] Context-dependent effects of yolk androgens on nestling growth and immune function in a multibrooded passerine
Muriel, J.
Salmon, P.
Nunez-Buiza, A.
de Salas, F.
Perez-Rodriguez, L.
Puerta, M.
Gil, D.
[J]. JOURNAL OF EVOLUTIONARY BIOLOGY, 2015, 28 (08) : 1476 - 1488
[7] A context-dependent vision system for pedestrian detection
Lombardi, P
Zavidovique, B
[J]. 2004 IEEE INTELLIGENT VEHICLES SYMPOSIUM, 2004, : 578 - 583
[8] A context-dependent attention system for a social robot
Breazeal, C
Scassellati, B
[J]. IJCAI-99: PROCEEDINGS OF THE SIXTEENTH INTERNATIONAL JOINT CONFERENCE ON ARTIFICIAL INTELLIGENCE, VOLS 1 & 2, 1999, : 1146 - 1151
[9] Context-dependent effects of inflammation on retina regeneration
Cuiping Zhou
Xiaoli Zhang
Yuxi Chen
Zihao Lin
Shuqiang Zhang
Zhiqiang Zhang
Lining Cao
Huaijin Guan
Jianfeng Lu
Hui Xu
[J]. Molecular Neurobiology, 2022, 59 : 4351 - 4367
[10] Acamprosate reduces context-dependent ethanol effects
Quertemont, E
Brabant, C
De Witte, P
[J]. PSYCHOPHARMACOLOGY, 2002, 164 (01) : 10 - 18

← 1 2 3 4 5 →