A New Strategy for the Synthesis of Poly-Substituted 3-H, 3-Fluoro, or 3-Trifluoromethyl Pyridines via the Tandem C-F Bond Cleavage Protocol

被引：33

作者：

Chen, Zixian ^{[1
,2
]}

Zhu, Jiangtao ^{[1
]}

Xie, Haibo ^{[1
]}

Li, Shan ^{[1
]}

Wu, Yongming ^{[1
]}

Gong, Yuefa ^{[2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[2] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 19期

基金：

美国国家科学基金会;

关键词：

ONE-POT SYNTHESIS; ANTIBACTERIAL AGENTS; HERBICIDAL ACTIVITY; COUPLING REACTIONS; FACILE SYNTHESIS; DERIVATIVES; AMINOPYRIDINES; DIAZOTIZATION; EFFICIENT; IODIDES;

D O I：

10.1021/ol101859p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy for the synthesis of poly-substituted 3-H, 3-F, and 3-trifluoromethyl pyridines based on C-F bond breaking of the anionically activated fluoroalkyl group is described. A series of 2,6-disubstituted 4-amino pyridines were prepared through this domino process in high yields under noble metal-free conditions, making this method a supplement to pyridine synthesis.

引用

页码：4376 / 4379

页数：4

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