1,6-Conjugate-Addition-Induced [2+1] Annulation of para-Quinone Methides and Pyrazolones: Synthesis of Bis-Spiro Compounds with Contiguous Quaternary Spiro-Centers

被引：32
|
作者：
Kale, Someshwar B. [1 ,3 ]
Jori, Popat K. [1 ]
Thatikonda, Thanusha [1 ]
Gonnade, Rajesh G. [2 ,3 ]
Das, Utpal [1 ,3 ]
机构：
[1] Natl Chem Lab, Div Organ Chem, CSIR, Pune 411008, Maharashtra, India
[2] Natl Chem Lab, Ctr Mat Characterizat, CSIR, Pune 411008, Maharashtra, India
[3] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 19期
关键词：
CATALYTIC ENANTIOSELECTIVE CONSTRUCTION; 1,6-CONJUGATE ADDITION; DNA ALKYLATION; SULFONIUM SALTS; DEAROMATIZATION; SPIROCYCLOPROPANATION; TEMPERATURE;
D O I：
10.1021/acs.orglett.9b02641
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A diastereoselective formal 1,6-conjugate-addition-mediated [2 + 1] annulation reaction using p-quinone methides and pyrazolones has been described. The corresponding bis-spiro[cyclohexadienone-cyclopropane-pyrazolone] compounds were obtained in very good yield under mild reaction conditions.
引用
收藏
页码：7736 / 7740
页数：5
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