Homology Modelling of Human E1 Ubiquitin Activating Enzyme

被引：5

作者：

Brahemi, Ghali ^{[1
]}

Burger, Angelika M. ^{[2
]}

Westwell, Andrew D. ^{[1
]}

Brancale, Andrea ^{[1
]}

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Cardiff CF10 3NB, S Glam, Wales

[2] Wayne State Univ, Barbara Ann Karmanos Canc Inst, Hudson Webber Canc Res Ctr, Detroit, MI 48201 USA

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 01期

关键词：

Ubiquitination; Human E1; Ubiquitin activating enzyme; Homology modelling; STRUCTURAL BASIS; INSIGHTS; COMPLEX; RECRUITMENT; CONJUGATION; INHIBITOR; PATHWAY; CANCER; NEDD8;

D O I：

10.2174/157018010789869316

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.

引用

页码：57 / 62

页数：6

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