Anti-Hepatitis B Virus X Protein in Sera Is One of the Markers of Development of Liver Cirrhosis and Liver Cancer Mediated by HBV

被引：14
|
作者：
Zhang, Hang [2 ]
Wu, Lian-Ying [1 ]
Zhang, Shuai [2 ]
Qiu, Li-Yan [2 ]
Li, Nan [2 ]
Zhang, Xuan [2 ]
Zhang, Xue-Zhi [2 ]
Shan, Chang-Liang [2 ]
Ye, Li-Hong [1 ]
Zhang, Xiao-Dong [2 ]
机构：
[1] Nankai Univ, Coll Life Sci, Dept Biochem, Tianjin 300071, Peoples R China
[2] Nankai Univ, Coll Life Sci, Inst Mol Biol, Minist Educ,Dept Canc Res,Key Lab Mol Microbiol &, Tianjin 300071, Peoples R China
来源：
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2009年
关键词：
HEPATOCELLULAR-CARCINOMA; MONOCLONAL-ANTIBODY; INFECTION; DNA; IDENTIFICATION; INTEGRATION; EXPRESSION; CARRIERS; EPITOPE; LEVEL;
D O I：
10.1155/2009/289068
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Hepatitis B virus X protein (HBx) plays a crucial role in the development of hepatocellular carcinoma (HCC). However, the significance of circulating antibody to hepatitis B virus X antigen (anti-HBx) in sera remains unclear. In the present study, we examined the titers of anti-HBx (IgG) in the sera from 173 patients with chronic hepatitis B (CHB), 106 liver cirrhosis (LC), and 61 HCC by enzyme-linked immunosorbent assay (ELISA), respectively. Our data showed that the positive rates of anti-HBx were higher in sera of LC (40.6%) and HCC (34.4%) than those of CHB (10.4%), P < .05. In all 40 patients with anti-HBx+ out of 340 patients, 39 (97.5%) were HBsAg/HBeAg/anti-HBc+ and 1 (2.5%) was anti-HBs+ (P < .01), suggesting that anti-HBx in sera is a marker of HBV replication rather than a protective antibody. Thus, our findings reveal that circulating anti-HBx in sera is one of the markers of development of LC and HCC mediated by HBV. Copyright (C) 2009 Hang Zhang et al.
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页数：6
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