Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α

被引：6
|
作者：
Takemoto, Shinnosuke [1 ,2 ]
Soda, Hiroshi [1 ]
Iwasaki, Keisuke [3 ]
Kitazaki, Takeshi [1 ,4 ]
Sumiyoshi, Makoto [1 ]
Harada, Tatsuhiko [1 ]
Dotsu, Yosuke [1 ]
Ogawara, Daiki [1 ]
Fukahori, Susumu [1 ]
Fukuda, Yuichi [1 ]
Mukae, Hiroshi [2 ]
机构：
[1] Sasebo City Gen Hosp, Dept Resp Med, Sasebo, Nagasaki, Japan
[2] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki, Nagasaki, Japan
[3] Sasebo City Gen Hosp, Dept Pathol, Sasebo, Nagasaki, Japan
[4] Japan Red Cross Nagasaki Genbaku Hosp, Dept Resp Med, Nagasaki, Nagasaki, Japan
来源：
INTERNAL MEDICINE | 2017年 / 56卷 / 07期
关键词：
pulmonary artery sarcoma; PDGFR alpha; PET/CT scans; endovascular catheter biopsy;
D O I：
10.2169/internalmedicine.56.7731
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor a (PDGFR alpha) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFR alpha is known to be involved in cell proliferation in certain malignancies. PDGFR alpha may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFR alpha was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans.
引用
收藏
页码：823 / 826
页数：4
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