Asymmetric Hydrophosphonylation of Aldehydes using a Cinchona-Diaminomethylenemalononitrile Organocatalyst

被引：41

作者：

Hirashima, Shin-ichi ^{[1
]}

Arai, Ryoga ^{[1
]}

Nakashima, Kosuke ^{[1
]}

Kawai, Nobuaki ^{[1
]}

Kondo, Junko ^{[1
]}

Koseki, Yuji ^{[1
]}

Miura, Tsuyoshi ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Hachioji, Tokyo 1920392, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 18期

关键词：

asymmetric reactions; diaminomethylenemalononitrile; hydrophosphonylation; organocatalysts; Pudovik reaction; ALPHA-HYDROXY PHOSPHONATES; CATALYZED ENANTIOSELECTIVE HYDROPHOSPHONYLATION; CONJUGATE ADDITION; AL(SALALEN) COMPLEX; THIOUREA; INHIBITORS; PHOSPHITE; DESIGN; IMINES; ACCESS;

D O I：

10.1002/adsc.201500816

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

For the asymmetric hydrophosphonylation of aldehydes, an efficient organocatalytic approach with a diaminomethylenemalononitrilebased hydrogen-bonding donor catalyst is presented. The catalyst induces high yields and excellent enantioselectivities (up to 98% yield, 96% ee).

引用

页码：3863 / 3867

页数：5

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