The gRAss Is Greener: Potential new Therapies in Lung cancer with Acquired Resistance to KRAsG12c Inhibitors

被引:6
|
作者
Pinnelli, Marika [1 ,2 ]
Trusolino, Livio [1 ,2 ]
机构
[1] Univ Torino, Dept Oncol, Turin, Italy
[2] Candiolo Canc Inst FPO IRCCS, Turin, Italy
基金
欧盟地平线“2020”;
关键词
D O I
10.1158/2159-8290.CD-21-0609
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Inhibitors of KRAS(G12C) that bind the target in its inactive conformation and lock it in off-mode have shown early signs of clinical activity in patients with KRAS(G12C)-mutant lung cancer, but responses tend to be short-lived and invariably prelude the development of acquired resistance through largely unexplored mechanisms. A new study describes the emergence of RAS-MAPK heterogeneous subclonal alterations in a patient relapsed on a KRAS(G12C) inactive-state inhibitor and identifies a novel KRAS(Y96D)-resistant variant that is druggable by a next-generation compound capable of associating with KRAS(G12C) in its active configuration.
引用
收藏
页码:1874 / 1876
页数:3
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