INTERINDIVIDUAL VARIABILITY IN CYP2D6 ACTIVITY IN HUMAN LIVER MICROSOMES TO CHARACTERIZE RARE GENETIC VARIATION.

被引：0
|
作者：
Dalton, R. [1 ]
Phillips, B. [2 ]
Risler, L. [2 ]
Shen, D. D. [2 ]
Woodahl, E. L. [1 ]
机构：
[1] Univ Montana, Missoula, MT 59812 USA
[2] Univ Washington, Seattle, WA 98195 USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2015年 / 97卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
PII-023
引用
收藏
页码：S65 / S66
页数：2
相关论文
共 50 条
  • [1] Timolol metabolism in human liver microsomes is mediated principally by CYP2D6
    Volotinen, Marjo
    Turpeinen, Miia
    Tolonen, Ari
    Uusitalo, Jouko
    Maenpaa, Jukka
    Pelkonen, Olavi
    DRUG METABOLISM AND DISPOSITION, 2007, 35 (07) : 1135 - 1141
  • [2] CYP2D6 genetic variation in Ugandans
    Jun Miura
    Celestino Obua
    Catherine Abbo
    Tomonori Tateishi
    Sunao Kaneko
    European Journal of Clinical Pharmacology, 2022, 78 : 155 - 157
  • [3] CYP2D6 genetic variation in Ugandans
    Miura, Jun
    Obua, Celestino
    Abbo, Catherine
    Tateishi, Tomonori
    Kaneko, Sunao
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2022, 78 (01) : 155 - 157
  • [4] Metabolism of pimozide by CYP3A and CYP2D6 in human liver microsomes.
    Flockhart, DA
    Richard, E
    Soukova, N
    Kerbusch, T
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1997, 61 (02) : PIV65 - PIV65
  • [5] Formation of glutathione adduct metabolites of MDA in human liver microsomes is related to CYP2D6 activity
    Easton, N
    O'Shea, E
    Kingston, S
    Fry, JR
    Marsden, CA
    BRITISH JOURNAL OF PHARMACOLOGY, 2003, 138 : U97 - U97
  • [6] CYP2D6 Protein Level Is the Major Contributor to Interindividual Variability in CYP2D6-Mediated Drug Metabolism in Healthy Human Liver Tissue
    Ning, Miaoran
    Duarte, Julio D.
    Rubin, Leah H.
    Jeong, Hyunyoung
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 104 (05) : 974 - 982
  • [7] CYP2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes.
    Court, MH
    Duan, SX
    Hesse, LM
    Greenblatt, DJ
    FASEB JOURNAL, 2000, 14 (08): : A1338 - A1338
  • [8] INTERACTIONS BETWEEN THREE CYP2D6 SUBSTRATES IN HUMAN LIVER MICROSOMES.
    Kothiya, P.
    Zheng, X.
    Masters, A. R.
    Jones, D. R.
    Quinney, S. K.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 103 : S85 - S85
  • [9] Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes
    Senda, C
    Yamaura, Y
    Kobayashi, K
    Fujii, H
    Minami, H
    Sasaki, Y
    Igarashi, T
    Chiba, K
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 52 (01) : 100 - 103
  • [10] Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes
    He, Nu
    Xie, Hong-Guang
    Collins, Xavier
    Edeki, Timi
    Yan, Zhengyin
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2006, 33 (09): : 813 - 815
12345