Pixantrone maleate - Topoisomerase II inhibitor DNA intercalating agent oncolytic

被引：2
|
作者：
Lolli, Francesco
Tredici, Giovanni
Cavaletti, Guido
机构：
[1] Univ Florence, Dipartimento Sci Neurol & Psichiat, I-50127 Florence, Italy
[2] Univ Milano Bicocca, Dipartimento Neurosci & Tecnol Biomed, I-20052 Monza, Italy
来源：
DRUGS OF THE FUTURE | 2007年 / 32卷 / 08期
关键词：
D O I：
10.1358/dof.2007.032.08.1123409
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pixantrone is a noncardiotoxic aza-anthracenedione antineoplastic agent related to mitoxantrone. They share the same cytotoxic mechanism of action, interacting with DNA as intercalating agents via inhibition of topoisomerase II. The efficacy of pixantrone as an antineoplastic drug has been demonstrated in phase II/III clinical studies. Pixantrone is also extremely interesting as a putative immunosuppressant; at equiactive doses it is less cardiotoxic than mitoxantrone and it shows similar in vitro and in vivo immunological effects.
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页码：703 / 706
页数：4
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