Potential role of adenosine monophosphate-activated protein kinase in regulation of energy metabolism in dairy goat mammary epithelial cells

被引：12

作者：

Zhang, N. ^{[1
]}

Li, Q. Z. ^{[1
]}

Gao, X. J. ^{[1
]}

Yan, H. B. ^{[1
]}

机构：

[1] NE Agr Univ, Minist Educ, Key Lab Dairy Sci, Harbin 150030, Peoples R China

来源：

JOURNAL OF DAIRY SCIENCE | 2011年 / 94卷 / 01期

关键词：

5 '-adenosine monophosphate-activated protein kinase; dairy goat; mammary; ACETYL-COA CARBOXYLASE; GLUCOSE-TRANSPORT; SKELETAL-MUSCLE; EXPRESSION; AICAR; GENE; TRANSLOCATION; EXERCISE; GLUT1; AMPK;

D O I：

10.3168/jds.2010-3386

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The 5'-adenosine monophosphate-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. 5'-Adenosine monophosphate-activated protein kinase controls glucose and lipid metabolism in skeletal muscle, liver, and adipose tissues. The aim of this study was to investigate the effects of AMPK on glucose and lipid metabolism in dairy goat mammary epithelial cells. Treatment of mammary epithelial cells with an AMPK activator (5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside) dramatically increased glucose uptake and glucose transporter-1 mRNA abundance, and decreased levels of glycogen synthase 1 mRNA. Activation of AMPK also induced an increase in carnitine palmitoyl transferase 1 mRNA and decreases in fatty acid synthase and acetyl-CoA carboxylase 1 mRNA. These results suggest that AMPK is involved in the regulation of energy metabolism in dairy goat mammary epithelial cells.

引用

页码：218 / 222

页数：5

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