Intramolecular palladium-catalyzed direct arylation of alkenyl triflates

被引：33
|
作者：
Cruz, Ana C. F.
Miller, Neil D.
Willis, Michael C. [1 ]
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[2] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
[3] GlaxoSmithKline, Harlow CM19 5AW, Essex, England
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 21期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1021/ol702044z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A catalyst generated from Pd(OAC)(2) and dppp is effective for the direct intramolecular arylation of alkenyl triflates. Conjugated alkene-arene-containing carbocycles are produced in good yield. The process tolerates a variety of aryl substituents as well a simple heteroaryl groups. Electron-deficient aryl rings deliver faster reactions.
引用
收藏
页码：4391 / 4393
页数：3
相关论文
共 50 条
  • [1] PALLADIUM-CATALYZED PHOSPHORYLATION OF ALKENYL TRIFLATES
    HOLT, DA
    ERB, JM
    [J]. TETRAHEDRON LETTERS, 1989, 30 (40) : 5393 - 5396
  • [2] Palladium-Catalyzed Intramolecular Direct Arylation for Phosphorus Heterocycle Synthesis
    Chen, Yun-Rong
    Duan, Wei-Liang
    [J]. SYNTHESIS-STUTTGART, 2014, 46 (08): : 1067 - 1072
  • [3] Mild and efficient palladium-catalyzed intramolecular direct arylation reactions
    Lafrance, Marc
    Lapointe, David
    Fagnou, Keith
    [J]. TETRAHEDRON, 2008, 64 (26) : 6015 - 6020
  • [4] Palladium-catalyzed intramolecular α-arylation of sulfoximines
    Bolm, C
    Okamura, H
    Verrucci, M
    [J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2003, 687 (02) : 444 - 450
  • [5] Fluoradenes via palladium-catalyzed intramolecular arylation
    Rong, Lingling
    Liu, Qiancai
    Shi, Yingbo
    Tang, Jie
    [J]. CHEMICAL COMMUNICATIONS, 2011, 47 (07) : 2155 - 2157
  • [6] Asymmetric Palladium-Catalyzed Intramolecular α-Arylation of Aldehydes
    Garcia-Fortanet, Jorge
    Buchwald, Stephen L.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (42) : 8108 - 8111
  • [7] Direct Palladium-Catalyzed β-Arylation of Lactams
    Chen, Ming
    Liu, Feipeng
    Dong, Guangbin
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (14) : 3815 - 3819
  • [8] Direct palladium-catalyzed arylation of cyclopropenes
    Chuprakov, S
    Rubin, M
    Gevorgyan, V
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (11) : 3714 - 3715
  • [9] Palladium-Catalyzed Direct Arylation of Selenophene
    Rampon, Daniel S.
    Wessjohann, Ludger A.
    Schneider, Paulo H.
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2014, 79 (13): : 5987 - 5992
  • [10] Palladium-Catalyzed intramolecular direct arylation of aromatic tertiary amide compounds revisited
    Takagi, Koji
    Maeda, Asuka
    Tsunekawa, Ryotaro
    [J]. RESULTS IN CHEMISTRY, 2022, 4
12345