Precision medicine for advanced colorectal and gastroesophageal cancer

Colorectal and gastroesophageal cancer have a global high incidence and a high mortality rate. Surgery persists as the only curative therapy for patients with early stages of both diseases. In those patients that are diagnosed with metastatic or unresectable cancer, or that become metastatic after locoregional treatment, chemotherapy has been the traditional therapy, with rather poor results in terms of survival or progression free survival. Precision medicine using molecular markers is changing this situation. Herein we review the most relevant aspects with regards to advances in the treatment of both diseases.