Potential of [11C]DASB for measuring endogenous serotonin with PET:: binding studies

被引：27
|
作者：
Lundquist, P
Wilking, H
Höglund, AU
Sandell, J
Bergström, M
Hartvig, P
Långström, B
机构：
[1] Uppsala Univ, Dept Pharmaceut Biosci, Div Pharmacokinet & Drug Therapy, SE-75124 Uppsala, Sweden
[2] Univ Uppsala Hosp, Hosp Pharm, SE-75185 Uppsala, Sweden
[3] Uppsala Imanet, SE-75109 Uppsala, Sweden
来源：
NUCLEAR MEDICINE AND BIOLOGY | 2005年 / 32卷 / 02期
关键词：
positron emission tomography; brain; SERT (serotonin transporter); release;
D O I：
10.1016/j.nucmedbio.2004.12.001
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The serotonin transporter radioligand [C-11]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile, or [C-11]DASB, was examined in order to assess its potential for measuring fluctuations in endogenous serotonin concentrations with positron emission tomography. Binding characteristics of [C-11]DASB and the propensity for serotonin to displace the tracer were explored in rat brain homogenates. Experiments showed that serotonin displaced [C-11]DASB in vitro. Ex vivo experiments performed after tranylcypromine injection (3 or 15 mg/kg) showed a dose-dependent trend in radioactivity uptake and suggested that serotonin may compete with [C-11]DASB for transporter binding. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：129 / 136
页数：8
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