CCN1 EXPRESSION BY FIBROBLASTS HAS A ROLE IN BLEOMYCIN INDUCED SKIN FIBROSIS AND IS A POTENTIAL TARGET FOR ANTI-FIBROTIC THERAPY IN SCLERODERMA

被引:0
|
作者
Quensel, K. [1 ]
Hutchenreuther, J. [1 ]
Xu, S. [2 ]
Hinz, B. [3 ]
Siqueira, W. [1 ]
O'Gorman, D. [4 ]
Stratton, R. [2 ]
Leask, A. [1 ]
机构
[1] Univ Western Ontario, Dent, London, England
[2] UCL, London, England
[3] Univ Toronto, Toronto, ON, Canada
[4] Lawson Res Inst, London, ON, Canada
关键词
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A-109
引用
收藏
页码:A12 / A12
页数:1
相关论文
共 39 条
  • [31] Daidzein exhibits anti-fibrotic effect by reducing the expresslions of Proteinase activated receptor 2 and TGFβ1/smad mediated inflammation and apoptosis in Bleomycin-induced experimental pulmonary fibrosis
    Soumyakrishnan, Syamala
    Divya, Thomas
    Kalayarasan, Srinivasan
    Sriram, Narayanan
    Sudhandiran, Ganapasam
    BIOCHIMIE, 2014, 103 : 23 - 36
  • [32] EGR-1, a potential regulator of fibrosis, is up-regulated by SMAD3 and TGF-β in human skin fibroblasts, bleomycin-treated mice and scleroderma patients.
    Chen, SJ
    Takagawa, S
    Mori, Y
    Varga, J
    ARTHRITIS AND RHEUMATISM, 2003, 48 (09): : S668 - S669
  • [33] Anti-CX3CL1 monoclonal antibody therapy suppresses the development of bleomycin-induced and growth factors-induced skin fibrosis in mice
    Vu Huy Luong
    Chino, Takenao
    Oyama, Noritaka
    Obara, Takashi
    Kuboi, Yoshikazu
    Ishii, Naoto
    Machinaga, Akihito
    Ogasawara, Hideaki
    Ikeda, Wataru
    Imai, Toshio
    Hasegawa, Minoru
    CYTOKINE, 2017, 100 : 44 - 44
  • [34] Regulation of SMAD7 and SOCS1 Through Metabolic and Epigenetics Crosstalk by Mesenchymal Stem Cell-Derived Humoral Factor STC1 Induces Anti-Fibrotic and Anti-Inflammatory Effects in Bleomycin-Induced Lung Fibrosis Model
    Ohkouchi, S.
    Irokawa, T.
    Ogawa, H.
    Kurosawa, H.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2022, 205
  • [35] PBI-4050, A NOVEL FIRST-IN-CLASS ANTI-FIBROTIC COMPOUND, INHIBITS CTGF, α-SMA AND COLLAGEN EXPRESSION IN HUMAN FIBROBLASTS, AND REDUCES KIDNEY FIBROSIS IN 5/6-NEPHRECTOMIZED AND DOXORUBICIN-INDUCED NEPHROTOXICITY MODELS
    Leduc, Martin
    Gervais, Liette
    Geerts, Lilianne
    Grouix, Brigitte
    Sarra-Bournet, Francois
    Felton, Alexandra
    Abbott, Shaun
    Duceppe, Jean-Simon
    Zacharie, Boulos
    Penney, Christopher
    Laurin, Pierre
    Gagnon, Lyne
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2013, 28 : 27 - 27
  • [36] Protective effects of microbial biosurfactants produced by Bacillus halotolerans and Candida parapsilosis on bleomycin-induced pulmonary fibrosis in mice: Impact of antioxidant, anti-inflammatory and anti-fibrotic properties via TGF- β1/Smad-3 pathway and miRNA-326
    Mousa, Amria M.
    Nooman, Mohamed U.
    Abbas, Samah S.
    Gebril, Sahar M.
    Abdelraof, Mohamed
    Al-kashef, Amr S.
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2024, 486
  • [37] Salinomycin Induces Potent Suppression of TGF-β1-Mediated Expression of Profibrotic Genes in Cultured Dermal Fibroblasts from Normal Donors and from Donors with Systemic Sclerosis (SSc): A Novel Anti-Fibrotic Treatment for Tissue Fibrosis in SSc
    Wermuth, Peter J.
    Jimenez, Sergio A.
    ARTHRITIS & RHEUMATOLOGY, 2015, 67
  • [38] MRI-1867, Dual Target Cannabinoid Receptor 1 (CB1R) and Inducible Nitric Oxide Synthase (iNOS) Inhibitor, for Effective Anti-Fibrotic Therapy for Hermansky-Pudlak Syndrome Pulmonary Fibrosis in Pale Ear Mic
    Cinar, R.
    Iyer, M. R.
    Park, J. K.
    Zawatsky, C. N.
    Coffey, N. J.
    Bodine, S. P.
    Abdalla, J.
    Zuo, M. G.
    Gahl, W. A.
    Gochuico, B. R.
    Malicdan, M. V.
    Kunos, G.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [39] Transforming Growth Factor-β-Induced Expression Of Inhibin βa (activin A), A Potential Therapeutic Target In Lung Fibrosis, Is Blocked By Bromodomain Inhibitor Jq1 In Primary Adult Pulmonary Fibroblasts
    Lindahl, G.
    Stock, C.
    Leoni, P.
    Michaeloudes, C.
    Karagiannis, K.
    Maher, T. M.
    Sato, H.
    Wells, A. U.
    Chung, K.
    Adcock, I. M.
    Renzoni, E.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 189