Bacteria;
breast cancer;
probiotics;
treatment;
in vitro studies;
in vivo studies;
clinical trials;
PROGESTERONE-RECEPTOR STATUS;
LACTIC-ACID BACTERIA;
GUT MICROBIOTA;
LACTOBACILLUS-ACIDOPHILUS;
INTESTINAL MICROFLORA;
ALCOHOL-CONSUMPTION;
FERMENTED MILK;
RISK;
ESTROGEN;
SURVIVAL;
D O I:
10.4081/oncol.2019.422
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Breast cancer is one of the most important causes of cancer-related morbidity and mortality in the world. Probiotics, as functional food, have the potential to act against breast cancer, as evidenced by cell-based and animal model experiments. Prohiotic may he useful in prevention or treatment of breast cancer by modulating the gastrointestinal bacteria and the systemic immune system. However, large-scale clinical trials and intensive research are mandatory to confirm the in vitro and in vim results and exploring the probiotics-related metabolic, immune, and molecular mechanisms in breast cancer. This current review summarizes the available data related to probiotics and theft potential role in the treatment of breast cancer.
机构:
Temple Univ Hosp & Med Sch, Dept Med, Hematol Oncol Sect, Philadelphia, PA 19140 USATemple Univ Hosp & Med Sch, Dept Med, Hematol Oncol Sect, Philadelphia, PA 19140 USA
Martin, James M.
Goldstein, Lori J.
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机构:
Fox Chase Canc Ctr, Dept Med Oncol, 7701 Burholme Ave, Philadelphia, PA 19111 USATemple Univ Hosp & Med Sch, Dept Med, Hematol Oncol Sect, Philadelphia, PA 19140 USA