Antiplatelet activity of benzylisoquinoline derivatives oxidized by cerium(IV) ammonium nitrate

被引:18
|
作者
Kuo, RY [1 ]
Chang, FR [1 ]
Wu, CC [1 ]
Patnam, R [1 ]
Wang, WY [1 ]
Du, YC [1 ]
Wu, YC [1 ]
机构
[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
关键词
D O I
10.1016/S0960-894X(03)00477-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Oxidation of 1-benzyl-3.4-dihydroisoquinolines with cerium(IV) ammonium nitrate (CAN) under mild condition yielded the mixture of corresponding 1-benzylisoquinolines (b-type) and 1-benzoylisoquinolines (a- or c-type) in an equal yields. The selective oxidation products (c-type) can be prepared by using MeCN instead of MeOH. In the antiplatelet assays, four inducers were employed. including AA. Col. PAF, and Thr. In the PAF or Col induced platelet aggregation, compounds belonging to a- and b-tvpe showed stronger inhibitory effects than aspirin. (C) 2003 Flsevier Ltd. All rights reserved.
引用
收藏
页码:2789 / 2793
页数:5
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