Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

被引：61

作者：

Ranta, Susanna ^{[1
,2
]}

Tuckuviene, Ruta ^{[3
]}

Makipernaa, Anne ^{[4
,5
]}

Albertsen, Birgitte K. ^{[6
]}

Frisk, Tony ^{[1
,2
]}

Tedgard, Ulf ^{[7
,8
,9
,10
]}

Jonsson, Olafur G. ^{[11
]}

Pruunsild, Kaie ^{[12
]}

Andersson, Nadine Gretenkort ^{[7
,8
,9
,10
]}

Gunnes, Maria Winther ^{[13
]}

Trakymiene, Sonata Saulyte ^{[14
]}

Frandsen, Thomas ^{[15
]}

Heyman, Mats ^{[1
,2
]}

Ruud, Ellen ^{[16
]}

Helgestad, Jon ^{[3
]}

机构：

[1] Karolinska Univ Hosp, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden

[2] Karolinska Inst, Stockholm, Sweden

[3] Aalborg Univ Hosp, Dept Paediat, Aalborg, Denmark

[4] Univ Helsinki, Cent Hosp, Childrens Hosp, Helsinki, Finland

[5] Univ Helsinki, Cent Hosp, Ctr Canc, Dept Haematol, Helsinki, Finland

[6] Aarhus Univ Hosp, Dept Paediat, DK-8000 Aarhus, Denmark

[7] Lund Univ, Dept Paediat, Univ Hosp, Malmo, Sweden

[8] Lund Univ, Dept Coagulat Disorders, Univ Hosp, Malmo, Sweden

[9] Skane Univ Hosp, Dept Paediat Haematol & Oncol, Malmo, Sweden

[10] Skane Univ Hosp, Dept Paediat Haematol & Oncol, Lund, Sweden

[11] Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland

[12] Tallinn Childrens Hosp, Dept Haematol Oncol, Tallinn, Estonia

[13] Haukeland Hosp, Dept Paediat, N-5021 Bergen, Norway

[14] Vilnius Univ Hosp, Santariskiu Klin, Childrens Hosp, Ctr Paediat Oncol & Haematol, Vilnius, Lithuania

[15] Rigshosp, Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, DK-2100 Copenhagen, Denmark

[16] Rigshosp, Oslo Univ Hosp, Dept Paediat Med, DK-2100 Copenhagen, Denmark

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2015年 / 168卷 / 04期

关键词：

cerebral sinovenous thrombosis; acute leukaemia; paediatric; SINOVENOUS THROMBOSIS; ISCHEMIC-STROKE; RISK; ASPARAGINASE; METAANALYSIS; PROTOCOL; CANCER;

D O I：

10.1111/bjh.13162

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

引用

页码：547 / 552

页数：6

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