Sestrins at the crossroad between stress and aging

被引：58

作者：

Lee, Jun Hee ^{[2
,3
]}

Bodmer, Rolf ^{[4
]}

Bier, Ethan ^{[1
]}

Karin, Michael ^{[2
,3
]}

机构：

[1] Univ Calif San Diego, Sect Cell & Dev Biol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Sch Med, Dept Pathol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

[4] Sanford Burnham Med Res Inst, Neurosci Aging & Stem Cell Res Ctr, Dev & Aging Program, La Jolla, CA 92037 USA

来源：

AGING-US | 2010年 / 2卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Sestrin; TOR; autophagy; stress; aging; hormesis; OXIDATIVE STRESS; LIFE-SPAN; HEART FUNCTION; DNA-DAMAGE; DROSOPHILA; P53; AUTOPHAGY; MTOR; GENE; PATHWAYS;

D O I：

10.18632/aging.100157

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced pathophysiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.

引用

页码：369 / 374

页数：6

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