Microwave-promoted Suzuki reactions of aryl chlorides in aqueous media

被引：61

作者：

Miao, GB ^{[1
]}

Ye, P ^{[1
]}

Yu, LB ^{[1
]}

Baldino, CM ^{[1
]}

机构：

[1] ArQule Inc, Woburn, MA 01801 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 06期

关键词：

D O I：

10.1021/jo047975c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The microwave-promoted Suzuki coupling reaction of aryl chlorides with boronic acids performed in an aqueous media was studied using the air- and moisture-stable catalyst POPd2 (dihydrogen di-mu-chlorodichlorobis(di-tert-butylphosphinito-kappa P)dipalladate (2-)). This catalyst system under microwave conditions (150 degrees C, 15 min) provided coupled products with yields ranging from 64% to 99%. This method tolerated a variety of substituents and sterically hindered substrates.

引用

页码：2332 / 2334

页数：3

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