Microwave-promoted Suzuki reactions of aryl chlorides in aqueous media

被引：61
|
作者：
Miao, GB [1 ]
Ye, P [1 ]
Yu, LB [1 ]
Baldino, CM [1 ]
机构：
[1] ArQule Inc, Woburn, MA 01801 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 06期
关键词：
D O I：
10.1021/jo047975c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The microwave-promoted Suzuki coupling reaction of aryl chlorides with boronic acids performed in an aqueous media was studied using the air- and moisture-stable catalyst POPd2 (dihydrogen di-mu-chlorodichlorobis(di-tert-butylphosphinito-kappa P)dipalladate (2-)). This catalyst system under microwave conditions (150 degrees C, 15 min) provided coupled products with yields ranging from 64% to 99%. This method tolerated a variety of substituents and sterically hindered substrates.
引用
收藏
页码：2332 / 2334
页数：3
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