Synthesis of Acyclic Nucleosides with a Chiral Amino Side Chain by the Mitsunobu Coupling Reaction

被引：40

作者：

Guo, Hai-Ming ^{[1
]}

Wu, Yan-Yan ^{[1
]}

Niu, Hong-Ying ^{[2
]}

Wang, Dong-Chao ^{[1
]}

Qu, Gui-Rong ^{[1
]}

机构：

[1] Henan Normal Univ, Coll Chem & Environm Sci, Key Lab Green Chem Media & React, Minist Educ, Xinxiang 453007, Henan, Peoples R China

[2] Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 11期

关键词：

ANTIVIRAL ACTIVITY; ANALOGS; VIRUS; (S)-9-(2,3-DIHYDROXYPROPYL)ADENINE; OLIGONUCLEOTIDES; PHOSPHONATES; ACYCLOVIR; CIDOFOVIR; BACKBONE;

D O I：

10.1021/jo100397a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient synthetic method has been developed Oar the preparation of chiral acyclic nucleosides with a chiral amino side chain by Mitsunobu reaction between nucleoside bases and protected L-serine. This method suggests a potentially more efficient and complementary process to acquire chiral acyclic nucleosides.

引用

页码：3863 / 3866

页数：4

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