A bioactive polyacetylene compound isolated from Centella asiatica

被引：24
|
作者：
Govindan, G.
Sambandan, T. G.
Govindan, M.
Sinskey, A.
Vanessendelft, J.
Adenan, I.
Rha, C. K.
机构：
[1] MIT, Biomat Sci & Engn Lab, Cambridge, MA 02139 USA
[2] Fitchburg State Coll, Dept Chem, Fitchburg, MA USA
[3] MIT, Dept Biol, Cambridge, MA USA
[4] Forest Res Inst Malaysia, Kepong Selangor, Malaysia
来源：
PLANTA MEDICA | 2007年 / 73卷 / 06期
关键词：
D O I：
10.1055/s-2007-981521
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A polyacetylene compound was isolated from the aerial parts of Centella asiatica. The chemical structure of this new compound was identified as methyl 5-[(E)-9-hydroxy-1-(1-hydroxyhexyl)2-methoxyundeca-3,10-diene-5,7-diynyloxy]pentanoate (cadiyenol). This compound induces apoptosis (63%) independent of cell cycle regimen in mouse lymphoma cells (P388D1) at 28 mu M (IC50 = 24 +/- 2 pM) in 24 hours. The compound also reduces nitric oxide production by 70 +/- 2 % in lipopolysacharrideactivated mouse macrophages at 24 pM with no measurable cytotoxicity.
引用
收藏
页码：597 / 599
页数：3
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