A bioactive polyacetylene compound isolated from Centella asiatica

被引：24
|
作者：
Govindan, G.
Sambandan, T. G.
Govindan, M.
Sinskey, A.
Vanessendelft, J.
Adenan, I.
Rha, C. K.
机构：
[1] MIT, Biomat Sci & Engn Lab, Cambridge, MA 02139 USA
[2] Fitchburg State Coll, Dept Chem, Fitchburg, MA USA
[3] MIT, Dept Biol, Cambridge, MA USA
[4] Forest Res Inst Malaysia, Kepong Selangor, Malaysia
来源：
PLANTA MEDICA | 2007年 / 73卷 / 06期
关键词：
D O I：
10.1055/s-2007-981521
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A polyacetylene compound was isolated from the aerial parts of Centella asiatica. The chemical structure of this new compound was identified as methyl 5-[(E)-9-hydroxy-1-(1-hydroxyhexyl)2-methoxyundeca-3,10-diene-5,7-diynyloxy]pentanoate (cadiyenol). This compound induces apoptosis (63%) independent of cell cycle regimen in mouse lymphoma cells (P388D1) at 28 mu M (IC50 = 24 +/- 2 pM) in 24 hours. The compound also reduces nitric oxide production by 70 +/- 2 % in lipopolysacharrideactivated mouse macrophages at 24 pM with no measurable cytotoxicity.
引用
收藏
页码：597 / 599
页数：3
相关论文
共 50 条
  • [1] A Novel Source of Bioactive Compounds: Endophytic Bacteria Isolated from Centella asiatica
    Rafat, Arash
    Philip, Koshy
    Muniandy, Sekaran
    JOURNAL OF PURE AND APPLIED MICROBIOLOGY, 2012, 6 (01): : 11 - 20
  • [2] Retention of Bioactive Compound in the Concentration of Centella Asiatica Extract through Progressive Freezing
    Amran, N. A.
    Rafee, N. H. Mohd
    Samsuri, S.
    26TH REGIONAL SYMPOSIUM ON CHEMICAL ENGINEERING (RSCE 2019), 2020, 778
  • [3] Influence of Varieties and Elicitors on Biomass and Bioactive Compound Yield of Centella Asiatica Growing in Pathumthani
    Amprayn, Khanok-on
    Chanchula, Nattapong
    Piriyapattarakit, Anan
    Sunthorn, Napassawan
    Premrit, Siriporn
    INTERNATIONAL TRANSACTION JOURNAL OF ENGINEERING MANAGEMENT & APPLIED SCIENCES & TECHNOLOGIES, 2022, 13 (06):
  • [4] Extraction of bioactive components from Centella asiatica using subcritical water
    Kim, Wan-Joo
    Kim, Jaehoon
    Veriansyah, Bambang
    Kim, Jae-Duck
    Lee, Youn-Woo
    Oh, Seong-Geun
    Tjandrawinata, Raymond R.
    JOURNAL OF SUPERCRITICAL FLUIDS, 2009, 48 (03): : 211 - 216
  • [5] Pharmacological effects of pentacyclic triterpenoids isolated from Centella asiatica
    Min, Dong-Hyun
    Yu, Young-Beom
    Kim, Tae-Hun
    Kim, Hoon
    Lee, Sanghyun
    HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY, 2024, 65 (02) : 189 - 197
  • [6] Pharmacological effects of pentacyclic triterpenoids isolated from Centella asiatica
    Dong-Hyun Min
    Young-Beom Yu
    Tae-Hun Kim
    Hoon Kim
    Sanghyun Lee
    Horticulture, Environment, and Biotechnology, 2024, 65 : 189 - 197
  • [7] EFFECT OF TERPENOIDS ISOLATED FROM CENTELLA-ASIATICA ON GRANULOMA TISSUE
    VOGEL, HG
    DESOUZA, NJ
    DSA, A
    ACTA THERAPEUTICA, 1990, 16 (04) : 285 - 298
  • [8] Anti-photoaging activity of triterpenoids isolated from Centella asiatica
    Dang, Yi-yun
    Liu, Tao
    Liu, Yu-die
    Li, Jia-yi
    Jing, Yi
    Yang, Miao-jie
    Zhang, Han
    Jiang, Miao-miao
    Wu, Hong-hua
    Yang, Wen-zhi
    Li, Nan
    Zhang, Peng
    PHYTOCHEMISTRY, 2024, 228
  • [9] Centella asiatica
    不详
    ALTERNATIVE MEDICINE REVIEW, 2007, 12 (01) : 69 - 72
  • [10] BIOACTIVE COMPOUND CONTENT AND ANTIOXIDANT CAPACITY DURING STORAGE OF DRY CENTELLA ASIATICA (LINN.) URBAN POMACE
    Thiyajai, Paranya
    Jittinandana, Sitima
    Nittithamyong, Anadi
    Chitchumroonchokchai, Chureeporn
    ANNALS OF NUTRITION AND METABOLISM, 2009, 55 : 382 - 382
12345