Mitochondrial dynamics altered by oxidative stress in cancer

被引：66

作者：

Kim, Boyun ^{[1
,2
]}

Song, Yong Sang ^{[1
,3
,4
]}

机构：

[1] Seoul Natl Univ, Canc Res Inst, Coll Med, Seoul, South Korea

[2] Seoul Natl Univ, Nano Syst Inst, Seoul, South Korea

[3] Seoul Natl Univ, Dept Agr Biotechnol, WCU Biomodulat, Seoul, South Korea

[4] Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea

来源：

FREE RADICAL RESEARCH | 2016年 / 50卷 / 10期

关键词：

Mitochondrial dynamics; reactive oxygen species; chemoresistance; metastasis; cancer; FISSION; FUSION; DRP1; CELL; OPA1; PHOSPHORYLATION; FRAGMENTATION; LAMELLIPODIA; DYSFUNCTION; BIOGENESIS;

D O I：

10.1080/10715762.2016.1210141

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria as crucial organelles regulate cellular energy generation, calcium and redox homeostasis, and apoptosis. To perform the cellular functions effectively, mitochondria continuously change their structure and morphology through protein machineries controlling fission and fusion process (mitochondrial dynamics). Traditionally, many researches had focused on the interaction of mitochondrial dynamics and apoptosis. However, recent studies are reporting the alteration of mitochondrial dynamics in human diseases including many types of cancers. Considering that cancers maintain a high level of reactive oxygen species (ROS), mitochondrial dynamics can be influenced by oxidative stress. In this review, we will discuss the alteration of mitochondrial dynamics by ROS and its effect on metastasis and chemoresistance in cancers.

引用

页码：1065 / 1070

页数：6

共 50 条

[21] Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer
Pinti, Marcello
Gibellini, Lara
Liu, Yongzhang
Xu, Shan
Lu, Bin
Cossarizza, Andrea
CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 72 (24) : 4807 - 4824
[22] Pathological Roles of Mitochondrial Oxidative Stress and Mitochondrial Dynamics in Cardiac Microvascular Ischemia/Reperfusion Injury
Zhou, Hao
Toan, Sam
BIOMOLECULES, 2020, 10 (01)
[23] Oxidative damage in cells with altered mitochondrial content
Crammer, Cody
Hoffman, Kristen
Baur, Joseph
MITOCHONDRION, 2010, 10 (02) : 213 - 213
[24] Altered Mitochondrial Dynamics and Diabetic Keratopathy
Mohammad, Ghulam
Kowluru, Renu A.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2022, 63 (07)
[25] Oxidative stress and mitochondrial dysfunction
Heales, Simon
Land, John
Pope, Simon
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2008, 1777 : S45 - S45
[26] Oxidative Stress and Mitochondrial Dysfunction
Przedborski, S.
MOVEMENT DISORDERS, 2010, 25 : S595 - S595
[27] Mitochondrial Oxidative Stress in Hypertension
Dikalova, Anna E.
Bikineyeva, Alfiya T.
Harrison, David G.
Dikalov, Sergey I.
FREE RADICAL BIOLOGY AND MEDICINE, 2008, 45 : S143 - S143
[28] Oxidative stress generated during monensin treatment contributes to altered Toxoplasma gondii mitochondrial function
Charvat, Robert A.
Arrizabalaga, Gustavo
SCIENTIFIC REPORTS, 2016, 6
[29] The daily rhythms of mitochondrial gene expression and oxidative stress regulation are altered by aging in the mouse liver
Gong, Changxia
Li, Chengwei
Qi, Xiaoqing
Song, Zhiyin
Wu, Jianguo
Hughes, Michael E.
Li, Xiaodong
CHRONOBIOLOGY INTERNATIONAL, 2015, 32 (09) : 1254 - 1263
[30] Oxidative stress generated during monensin treatment contributes to altered Toxoplasma gondii mitochondrial function
Robert A. Charvat
Gustavo Arrizabalaga
Scientific Reports, 6

← 1 2 3 4 5 →