Mitochondrial dynamics altered by oxidative stress in cancer

被引：66
|
作者：
Kim, Boyun [1 ,2 ]
Song, Yong Sang [1 ,3 ,4 ]
机构：
[1] Seoul Natl Univ, Canc Res Inst, Coll Med, Seoul, South Korea
[2] Seoul Natl Univ, Nano Syst Inst, Seoul, South Korea
[3] Seoul Natl Univ, Dept Agr Biotechnol, WCU Biomodulat, Seoul, South Korea
[4] Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea
来源：
FREE RADICAL RESEARCH | 2016年 / 50卷 / 10期
关键词：
Mitochondrial dynamics; reactive oxygen species; chemoresistance; metastasis; cancer; FISSION; FUSION; DRP1; CELL; OPA1; PHOSPHORYLATION; FRAGMENTATION; LAMELLIPODIA; DYSFUNCTION; BIOGENESIS;
D O I：
10.1080/10715762.2016.1210141
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondria as crucial organelles regulate cellular energy generation, calcium and redox homeostasis, and apoptosis. To perform the cellular functions effectively, mitochondria continuously change their structure and morphology through protein machineries controlling fission and fusion process (mitochondrial dynamics). Traditionally, many researches had focused on the interaction of mitochondrial dynamics and apoptosis. However, recent studies are reporting the alteration of mitochondrial dynamics in human diseases including many types of cancers. Considering that cancers maintain a high level of reactive oxygen species (ROS), mitochondrial dynamics can be influenced by oxidative stress. In this review, we will discuss the alteration of mitochondrial dynamics by ROS and its effect on metastasis and chemoresistance in cancers.
引用
收藏
页码：1065 / 1070
页数：6
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