Functionalization of TiO2 for Better Performance as Orthopedic Implants

被引:5
|
作者
Noreen, Sehrish [1 ]
Wang, Engui [1 ]
Feng, Hongqing [1 ]
Li, Zhou [1 ]
机构
[1] Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing Inst Nanoenergy & Nanosyst, Beijing 100101, Peoples R China
基金
北京市自然科学基金; 国家重点研发计划; 中国国家自然科学基金;
关键词
TiO2; Ti implants; antibacterial properties; osteogenesis; functionalization; EXTRACELLULAR ELECTRON-TRANSFER; TITANIA NANOTUBE ARRAYS; ANTIBACTERIAL ACTIVITY; STEM-CELLS; IN-VITRO; INFECTION; COATINGS; SILVER; ZINC; NANOTOPOGRAPHY;
D O I
10.3390/ma15196868
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
This review mainly focuses on the surface functionalization approaches of titanium dioxide (TiO2) to prevent bacterial infections and facilitate osteointegration simultaneously for titanium (Ti)-based orthopedic implants. Infection is one of the major causes of implant failure. Meanwhile, it is also critical for the bone-forming cells to integrate with the implant surface. TiO2 is the native oxide layer of Ti which has good biocompatibility as well as enriched physical, chemical, electronic, and photocatalytic properties. The formed nanostructures during fabrication and the enriched properties of TiO2 have enabled various functionalization methods to combat the micro-organisms and enhance the osteogenesis of Ti implants. This review encompasses the various modifications of TiO2 in aspects of topology, drug loading, and element incorporation, as well as the most recently developed electron transfer and electrical tuning approaches. Taken together, these approaches can endow Ti implants with better bactericidal and osteogenic abilities via the functionalization of TiO2.
引用
收藏
页数:14
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