Novel access to 1,4-benzodiazepin-2-ones via the Buchwald reaction and application to the synthesis of novel heterocyclics

被引：8
|
作者：
Salome, Christophe [1 ]
Schmitt, Martine [1 ]
Bourguignon, Jean-Jacques [1 ]
机构：
[1] Fac Pharm, Lab Innovat Therapeut, UMR 7200, F-67401 Illkirch Graffenstaden, France
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 09期
关键词：
Buchwald; Pd crosscoupling; 1,4-Benzodiazepin-2-one; Pyridine; Pyridazine; ARYL HALIDES;
D O I：
10.1016/j.tetlet.2011.12.045
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new two step strategy for the preparation of 1,4-benzodiazepin-2-ones has been developed starting from the 2-halogenobenzophenone under Buchwald conditions (Pd(OAc)(2), XantPhos, Cs2CO3, dioxane 100 degrees C). This strategy has been extended to two 2-halogeno-3-benzoyl-azines (pyridines, pyridazines). (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1033 / 1035
页数：3
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