Outbreak investigation of Candida auris at a tertiary care hospital in Karachi, Pakistan

被引:7
|
作者
Farooqi, Joveria Q. [1 ]
Soomro, Asad S. [2 ]
Baig, Mirza A. [2 ]
Sajjad, Shamoona F. [2 ]
Hamid, Kamran [2 ]
Jabeen, Kauser [1 ]
Naqvi, Mohammed F. [1 ]
Nasir, Nosheen [3 ]
Roshan, Rozina [4 ]
Mahmood, Syed F. [3 ]
Zafar, Afia [1 ]
Asghar, Rana J. [5 ]
机构
[1] Aga Khan Univ, Dept Pathol & Lab Med, Stadium Rd,POB 3500, Karachi 74800, Sindh, Pakistan
[2] Field Epidemiol & Lab Training Program, Karachi, Pakistan
[3] Aga Khan Univ, Dept Med, Karachi, Pakistan
[4] Aga Khan Univ Hosp, Dept Qual & Patient Safety, Karachi, Pakistan
[5] Global Hlth Strategists & Implementers GHSI, Islamabad, Pakistan
关键词
Candida auris; outbreak investigation; fluconazole resistant; infection control;
D O I
10.1177/1757177420935639
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: From September 2014, a tertiary care hospital in Karachi, Pakistan, started diagnosing 3-5 cases/month of a yeast locally identified as Saccharomyces spp. resistant to fluconazole. US Centers for Disease Control and Prevention identified the isolates as Candida auris. The Pakistan Field Epidemiology and Laboratory Training Program (FELTP) and the hospital investigated the outbreak from April 2015 to January 2016. Objective: The aim of the outbreak investigation was to determine the risk factors and to inform measures to limit the spread of the organism in the hospital. Methods: Medical records, nursing schedules and infection control practices were reviewed. Sixty-two age- and sex-matched hospital controls from the same wards were identified. Results: Thirty cases (17 males) were identified (mean age = 51.6 years, age range = 2-91 years), case fatality was 53%. Multivariate logistic regression showed that a history of surgery within 90 days of diagnosis, admission to the emergency department and history of chronic kidney disease were significantly associated with C. auris infection. Discussion: This is the report of the outbreak investigation that triggered a global exploration of C. auris as a newly identified multidrug-resistant nosocomial organism, spreading within the hospital, especially among patients with invasive procedures. Unfortunately, we could not identify any specific source of the outbreak nor stop the transmission of the organism.
引用
收藏
页码:189 / 195
页数:7
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