Does CNS myelin inhibit axon regeneration?

被引：9
|
作者：
Fields, RD [1 ]
Schwab, ME [1 ]
Silver, J [1 ]
机构：
[1] NICHD, Neurocytol & Physiol Unit, NIH, Bethesda, MD 20892 USA
来源：
NEUROSCIENTIST | 1999年 / 5卷 / 01期
关键词：
NI35/250; axon regeneration; proteoglycan; gliosis; oligodendrocytes; astrocytes; myelin; spinal cord injury; extracellular matrix;
D O I：
10.1177/107385849900500103
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Membrane proteins on oligodendrocytes and CNS myelin (NI35/250) have been shown to block axon outgrowth in culture, and this is thought to be one of the major reasons for severely limited regeneration of severed axons in the CNS of higher vertebrates, In a recent study, adult dorsal root ganglion (DRG) neurons, which are sensitive to these inhibitory proteins, regenerated successfully after transplantation into two white matter tracts of the rat brain without any intervention to suppress the inhibitory activity of CNS myelin, The results and implications of these two studies are considered.
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页码：12 / 18
页数：7
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