Design principles for robust biochemical reaction networks: What works, what cannot work, and what might almost work

被引：48
|
作者：
Shinar, Guy [1 ]
Feinberg, Martin [2 ,3 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel
[2] Ohio State Univ, William G Lowrie Dept Chem & Biomol Engn, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Math, Columbus, OH 43210 USA
来源：
MATHEMATICAL BIOSCIENCES | 2011年 / 231卷 / 01期
关键词：
Network; Reaction network; Robust; Systems biology; Design principles; COMPLEX ISOTHERMAL REACTORS; CHEMICAL-REACTION NETWORKS; MULTIPLE STEADY-STATES; ISOCITRATE DEHYDROGENASE; PHOSPHATASE-ACTIVITY; ESCHERICHIA-COLI; PHOSPHORYLATION; ADAPTATION; GRADIENT; DEPHOSPHORYLATION;
D O I：
10.1016/j.mbs.2011.02.012
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We bring together recent results that connect the structure of a mass-action reaction network to its capacity for concentration robustness that is, its capacity to keep the concentration of a critical bioactive species within narrow limits, even against large fluctuations in the overall supply of the network's constituents. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：39 / 48
页数：10
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