Design principles for robust biochemical reaction networks: What works, what cannot work, and what might almost work

被引：48

作者：

Shinar, Guy ^{[1
]}

Feinberg, Martin ^{[2
,3
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel

[2] Ohio State Univ, William G Lowrie Dept Chem & Biomol Engn, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Math, Columbus, OH 43210 USA

来源：

MATHEMATICAL BIOSCIENCES | 2011年 / 231卷 / 01期

关键词：

Network; Reaction network; Robust; Systems biology; Design principles; COMPLEX ISOTHERMAL REACTORS; CHEMICAL-REACTION NETWORKS; MULTIPLE STEADY-STATES; ISOCITRATE DEHYDROGENASE; PHOSPHATASE-ACTIVITY; ESCHERICHIA-COLI; PHOSPHORYLATION; ADAPTATION; GRADIENT; DEPHOSPHORYLATION;

D O I：

10.1016/j.mbs.2011.02.012

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We bring together recent results that connect the structure of a mass-action reaction network to its capacity for concentration robustness that is, its capacity to keep the concentration of a critical bioactive species within narrow limits, even against large fluctuations in the overall supply of the network's constituents. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：39 / 48

页数：10

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