Synergistic Anticancer Effects Achieved by Co-Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles

被引：45
|
作者：
Lee, Ashlynn L. Z. [1 ,2 ]
Wang, Yong [1 ]
Pervaiz, Shazib [2 ]
Fan, Weimin [3 ]
Yang, Yi Yan [1 ]
机构：
[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore 117597, Singapore
[3] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
来源：
MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 02期
关键词：
drug delivery systems; nanoparticles; protein delivery; self-assembly; synergistic effects; APOPTOSIS-INDUCING LIGAND; CHEMOTHERAPEUTIC-AGENTS; HUMAN HEPATOCYTES; CANCER-CELLS; IN-VIVO; DRUGS; NANOPARTICLES; PATHWAY; PROTEIN; DEATH;
D O I：
10.1002/mabi.201000332
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cationic micellar nanoparticles self-assembled from a biodegradable amphiphilic copolymer have been used to deliver human TRAIL and paclitaxel simultaneously. Polyplexes formed between paclitaxel-loaded nanoparticles and TRAIL are stable with a size of approximate to 180 nm and a zeta potential at approximate to 75 mV. Anticancer effects and apoptotic pathway mechanisms of this drug-and-protein co-delivery system are investigated in various human breast cancer cell lines with different TRAIL sensitivity. The co-delivery nanoparticulate system induces synergistic anti-cancer activities with limited toxicity in non-cancerous cells. An advantage of this co-delivery is a significantly higher anti-cancer effect as compared to free drug and protein formulations.
引用
收藏
页码：296 / 307
页数：12
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