Past and future impact of next-generation sequencing in head and neck cancer

被引:4
|
作者
Sethi, Neeraj [1 ]
MacLennan, Kenneth [1 ]
Wood, Henry M. [1 ]
Rabbitts, Pamela [1 ]
机构
[1] St James Univ Hosp, Leeds Inst Canc & Pathol, Wellcome Trust Brenner Bldg, Leeds LS9 7TF, W Yorkshire, England
关键词
next-generation sequencing; head and neck cancer; Sanger sequencing; human papillomavirus; genomics; SQUAMOUS-CELL CARCINOMA; COPY-NUMBER; INTRATUMOR HETEROGENEITY; HUMAN-PAPILLOMAVIRUS; GENOMIC ANALYSIS; PI3K PATHWAY; DNA; MUTATIONS; EVOLUTION; TUMORS;
D O I
10.1002/hed.24085
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Progress in sequencing technology is intrinsically linked to progress in understanding cancer genomics. The purpose of this review was to discuss the development from Sanger sequencing to nextgeneration sequencing (NGS) technology. We highlight the technical considerations for understanding reports using NGS. We discuss the findings of studies in head and neck cancer using NGS as well as The Cancer Genome Atlas. Finally we discuss future routes for research utilizing this methodology and the potential impact of this. (C) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:E2395 / E2402
页数:8
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