Lessons learned from next-generation sequencing in head and neck cancer

被引：48

作者：

Loyo, Myriam ^{[1
]}

Li, Ryan J. ^{[1
]}

Bettegowda, Chetan ^{[2
]}

Pickering, Curtis R. ^{[3
]}

Frederick, Mitchell J. ^{[3
]}

Myers, Jeffrey N. ^{[3
]}

Agrawal, Nishant ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2013年 / 35卷 / 03期

基金：

美国国家卫生研究院;

关键词：

next generation sequencing; mutations; oncogene; tumor suppressor gene; head and neck squamous cell carcinoma; SQUAMOUS-CELL-CARCINOMA; GROWTH-FACTOR RECEPTOR; PHASE-II TRIAL; HUMAN-PAPILLOMAVIRUS; TUMOR-SUPPRESSOR; P53; GENE; OROPHARYNGEAL CANCER; H-RAS; SIGNALING PATHWAYS; THERAPEUTIC TARGET;

D O I：

10.1002/hed.23100

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Scientific innovation has enabled whole exome capture and massively parallel sequencing of cancer genomes. In head and neck cancer, next-generation sequencing has granted us further understanding of the mutational spectrum of squamous cell carcinoma. As a result of these new technologies, frequently occurring mutations were identified in NOTCH1, a gene that had not previously been implicated in head and neck cancer. The current review describes the most common mutations in head and neck cancer: TP53, NOTCH1, HRAS, PIK3CA, and CDKN2A. Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed. (C) 2012 Wiley Periodicals, Inc. Head Neck 35: 454-463, 2013

引用

页码：454 / 463

页数：10

共 50 条

[1] Next-generation sequencing of cancer genomes: lessons learned
Corrigan, Amber E.
Taylor, Robert
Rallis, Kathrine S.
[J]. FUTURE ONCOLOGY, 2021, 17 (31) : 4041 - 4044
[2] Past and future impact of next-generation sequencing in head and neck cancer
Sethi, Neeraj
MacLennan, Kenneth
Wood, Henry M.
Rabbitts, Pamela
[J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2016, 38 : E2395 - E2402
[3] Current Trends in Precision Medicine and Next-Generation Sequencing in Head and Neck Cancer
Roberto N. Solis
Dustin A. Silverman
Andrew C. Birkeland
[J]. Current Treatment Options in Oncology, 2022, 23 : 254 - 267
[4] Current Trends in Precision Medicine and Next-Generation Sequencing in Head and Neck Cancer
Solis, Roberto N.
Silverman, Dustin A.
Birkeland, Andrew C.
[J]. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2022, 23 (02) : 254 - 267
[5] Lessons Learned on How to Grow a Next-Generation Sequencing Diagnostic Laboratory
Fox, A. J.
Lieberman, D. B.
Li, B.
Sukhadia, S.
Daber, R. D.
Zhao, J.
Morrissette, J. J.
[J]. JOURNAL OF MOLECULAR DIAGNOSTICS, 2016, 18 (06): : 996 - 996
[6] HLA Typing by Next-Generation Sequencing Lessons Learned and Future Applications
Cornaby, Caleb
Weimer, Eric T.
[J]. CLINICS IN LABORATORY MEDICINE, 2022, 42 (04) : 603 - 612
[7] Next-Generation Sequencing of Lung Cancers Lessons Learned and Future Directions
Devarakonda, Siddhartha
Masood, Ashiq
Govindan, Ramaswamy
[J]. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2017, 31 (01) : 1 - +
[8] Oncogenic viruses: Lessons learned using next-generation sequencing technologies
Flippot, Ronan
Malouf, Gabriel G.
Su, Xiaoping
Khayat, David
Spano, Jean-Philippe
[J]. EUROPEAN JOURNAL OF CANCER, 2016, 61 : 61 - 68
[9] Lessons learned: next-generation sequencing applied to undiagnosed genetic diseases
Schuler, Bryce A.
Nelson, Erica T.
Koziura, Mary
Cogan, Joy D.
Hamid, Rizwan
Phillips, John A., III
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 (07):
[10] Next-generation sequencing: emerging lessons on the origins of human cancer
Pfeifer, Gerd P.
Hainaut, Pierre
[J]. CURRENT OPINION IN ONCOLOGY, 2011, 23 (01) : 62 - 68

← 1 2 3 4 5 →