Comparison of two in vitro methods to evaluate the water resistance of sunscreens

被引：1
|
作者：
Cheignon, C. [1 ]
Couteau, C. [1 ]
Billon-Chabaud, A. [2 ]
Da Silva, E. Marques [1 ]
Paparis, E. [1 ]
Coiffard, L. J. M. [1 ]
机构：
[1] Nantes Atlantique Univ, Univ Nantes, LPiC,Fac Pharm, MMS,EA2160, F-44000 Nantes, France
[2] Nantes Atlantique Univ, Lab Pharm Galen, F-44000 Nantes, France
来源：
PHARMAZIE | 2012年 / 67卷 / 02期
关键词：
CARE PRODUCTS;
D O I：
10.1691/ph.2012.1048
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
For a long time, the water resistance of sunscreens has been determined in vivo, according to Colipa's (Comite de Liaison des Industries de la Parfumerie) procedure. This method is not so ethical as healthy volunteers are irradiated, and can be replaced by an in vitro method which is easy and quick to perform. The objective of this work was to correlate the experimental device proposed by Choquenet et al. and the dissolutest (Sotax (R) AT6). This equipment is used in the pharmaceutical industry to control the tablets. The experimental conditions have been fixed to correlate the results obtained with both methods. The stirring speed for the dissolutest was fixed at 75 rpm, which is the speed value recommended by the European Pharmacopeia to study the dissolution over time of tablets.
引用
收藏
页码：116 / 119
页数：4
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