One-Step Homogeneous DNA Assay with Single-Nanoparticle Detection

被引：87
|
作者：
Han, Guojun [1 ]
Xing, Zhi [1 ]
Dong, Yanhua [1 ]
Zhang, Sichun [1 ]
Zhang, Xinrong [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Atom & Mol Nanosci, Educ Minist, Beijing 100084, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 15期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
aggregation; DNA; gold; mass spectrometry; nanoparticles; PLASMA-MASS SPECTROMETRY; RESONANCE ENERGY-TRANSFER; GOLD NANOPARTICLES; SCATTERING TECHNIQUE; MOLECULAR BEACONS; LIGHT-SCATTERING; HYBRIDIZATION; IMMUNOASSAY; PROBES; DIFFERENTIATION;
D O I：
10.1002/anie.201006838
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Staying single: A DNA hybridization assay employs gold-nanoparticle (AuNP) probes and single-particle inductively coupled plasma spectrometry (ICP-MS; see picture). The degree of aggregation of AuNPs is characterized by simultaneous measurement of decreased concentrations of the AuNP population and increased individual sizes. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3462 / 3465
页数：4
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