MICROWAVE-ASSISTED EFFICIENT SYNTHESIS OF 4-SUBSTITUTED AMINO-2-METHYLQUINOLINES CATALYZED BY p-TOLUENESULFONIC ACID

被引：3

作者：

Wang, Xiao-qin ^{[1
]}

Cai, Yuan-hong ^{[1
]}

Xie, Xiao-yang ^{[1
]}

Huang, Cui-ying ^{[1
]}

Li, Jia-yu ^{[1
]}

Chen, Wen-na ^{[1
]}

He, Ming-hua ^{[1
]}

Pan, Wen-jia ^{[1
]}

机构：

[1] Guangdong Med Univ, Sch Pharm, Dongguan 523808, Peoples R China

来源：

HETEROCYCLES | 2016年 / 92卷 / 10期

关键词：

ARYL HALIDES; RECYCLABLE CATALYSTS; DERIVATIVES; AMINATIONS; ARYLAMINES; ETHERS; LIGAND; BONDS;

D O I：

10.3987/COM-16-13516

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 4-subtituted amino-2-methylquinolines (3a-3o) were readily synthesized via the reaction of 4-chloro-2-methylquinoline with amines catalyzed by p-toluenesulfonic acid (TsoH) at 120 degrees C for 1 h under microwave-assisted organic synthesis (MAOS) condition. The yields of products 3a-3o were in range of 55-89%. This approach has advantages such as higher yield, shorter reaction time, lower costs, more convenience, and higher efficiency compared to the conventional method. The structures of the products were characterized by using H-1 NMR, C-13 NMR and HRMS. The reactivity of different amines was discussed.

引用

页码：1864 / 1873

页数：10

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