Serum levels of soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 in asymptomatic carriers of hepatitis C virus

被引：4
|
作者：
Fukuda, Y [1 ]
Nakano, I [1 ]
Katano, Y [1 ]
Marui, A [1 ]
Hayakawa, T [1 ]
机构：
[1] Nagoya Univ, Sch Med, Dept Internal Med 2, Showa Ku, Nagoya, Aichi 4668550, Japan
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1998年 / 26卷 / 06期
关键词：
asymptomatic carrier; chronic hepatitis C; hepatitis C virus; intercellular adhesion molecule-1; vascular cell adhesion molecule-1; soluble ICAM-1; soluble VCAM-1; ELISA;
D O I：
10.1177/030006059802600605
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
High levels of serum-soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) have been noted in patients with chronic hepatitis C. This study aimed to measure serum levels of sICAM-1 and sVCAM-1 in asymptomatic hepatitis C virus carriers and clarify the clinical significance of measuring soluble forms. Serum levels of sICAM-1 were significantly higher than in healthy controls but serum sVCAM-1 levels did not differ statistically from those in healthy controls. Liver biopsy obtained from 12 asymptomatic hepatitis C virus carriers showed evidence of hepatitis. Estimating sICAM-1 and sVCAM-1 in asymptomatic carriers may be helpful, especially in cases in which liver biopsy is not possible.
引用
收藏
页码：313 / 318
页数：6
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