Serum levels of soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 in liver disease, and their changes by treatment with interferon

被引：10
|
作者：
Marui, A [1 ]
Fukuda, Y [1 ]
Koyama, Y [1 ]
Nakano, I [1 ]
Urano, F [1 ]
Yamada, M [1 ]
Hayakawa, T [1 ]
机构：
[1] NAGOYA UNIV, SCH MED, DEPT INTERNAL MED 2, SHOWA KU, NAGOYA, AICHI 466, JAPAN
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1996年 / 24卷 / 03期
关键词：
intercellular adhesion molecule-1; vascular cell adhesion molecule-1; interferon; chronic hepatitis; liver cirrhosis; hepatocellular carcinoma;
D O I：
10.1177/030006059602400304
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured by an enzyme-linked immunosorbent assay in patients with chronic hepatitis (n = 57), liver cirrhosis (n = 19) and hepatocellular carcinoma (n = 33). Serum levels of sICAM-1 and sVCAM-1 were significantly higher in liver disease than those in controls (P < 0.0001 and P < 0.0005, respectively). A total of 22 patients with chronic hepatitis C were treated with interferon. Pretreatment levels of sICAM-1 and sVCAM-1 were not significantly different between complete responders and non-responders. In complete responders, serum sICAM-1 and sVCAM-1 levels 1 year after interferon treatment significantly decreased compared to the pretreatment levels (P < 0.005 and P < 0.05, respectively). Post-treatment levels of sICAM-1 and sVCAM-1 in complete responders were also significantly lower than those in nonresponders (P < 0.005 and P < 0.05, respectively). This suggests that monitoring soluble adhesion molecules might be useful in the follow-up of patients with liver disease.
引用
收藏
页码：258 / 265
页数：8
相关论文
共 50 条
  • [1] Plasma levels of soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1 and soluble endothelial leukocyte adhesion molecule-1 in Alzheimer's disease
    Iarlori, C.
    Gambi, D.
    Gambi, F.
    Lucci, I.
    Reale, M.
    [J]. EUROPEAN JOURNAL OF NEUROLOGY, 2005, 12 : 63 - 63
  • [2] A comparative study of serum soluble vascular cell adhesion molecule-1 and soluble intercellular adhesion molecule-1 in preeclampsia
    Phocas I.
    Rizos D.
    Papoulias J.
    Xyni K.
    Sarandakou A.
    Salamalekis E.
    [J]. Journal of Perinatology, 2000, 20 (2) : 114 - 119
  • [3] Serum levels of soluble intercellular adhesion molecule-1 and soluble endothelial leukocyte adhesion molecule-1 in Alzheimer's disease
    Rentzos, A
    Michalopoulou, M
    Nikolaou, C
    Cambouri, C
    Rombos, A
    Dimitrakopoulos, A
    Kapaki, E
    Vassilopoulos, D
    [J]. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 2004, 17 (04) : 225 - 231
  • [4] Serum levels of soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 in asymptomatic carriers of hepatitis C virus
    Fukuda, Y
    Nakano, I
    Katano, Y
    Marui, A
    Hayakawa, T
    [J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1998, 26 (06) : 313 - 318
  • [5] Levels of soluble vascular cell adhesion molecule-1 and soluble intercellular adhesion molecule-1 are increased in women with ovarian hyperstimulation syndrome
    Daniel, Y
    Geva, E
    Amit, A
    Baram, A
    Englander, T
    Kupferminc, MJ
    Fait, G
    Lessing, JB
    [J]. FERTILITY AND STERILITY, 1999, 71 (05) : 896 - 901
  • [6] Alterations in soluble intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in hemodialysis patients
    Rabb, H
    Calderon, E
    Bittle, PA
    Ramirez, G
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1996, 27 (02) : 239 - 243
  • [7] Soluble intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in asymptomatic dyslipidemic subjects
    Karasek, D.
    Vaverkova, H.
    Frysak, Z.
    Halenka, M.
    Jackuliakova, D.
    Novotny, D.
    Lukes, J.
    [J]. INTERNATIONAL ANGIOLOGY, 2011, 30 (05) : 441 - 450
  • [8] Soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and the development of symptomatic peripheral arterial disease in men
    Pradhan, AD
    Rifai, N
    Ridker, PM
    [J]. CIRCULATION, 2002, 106 (07) : 820 - 825
  • [9] Increased soluble form of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in intermittent claudication
    Brevetti, G
    De Caterina, M
    Ungaro, B
    Martone, VD
    Di Donato, AM
    Scopacasa, F
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 31 (02) : 498A - 498A
  • [10] Soluble intercellular adhesion molecule-1 and Graves' disease
    EscobarMorreale, HF
    Serrano, J
    Sancho, JM
    Varela, C
    [J]. THYROID, 1997, 7 (05) : 801 - 803
12345